Neoral 100mg Capsule

Uses of Neoral 100mg Capsule

• Prevents graft rejection following organ transplantation
• Treats auto-immune skin diseases such as psoriasis or atopic dermatitis
• Treats rheumatoid arthritis (joint inflammation)
• Treat nephrotic syndrome (a kidney disease)
• Treats eye inflammation (such as endogenous uveitis, including Behçet's uveitis)

How doesNeoral 100mg Capsule work?

Ciclosporin is an immunosuppressant. It works by suppressing your body’s immune response.

Side Effects of Neoral 100mg Capsule

• Decrease in blood cell count
• Tremors
• Headache
• Nausea and vomiting
• Skin rash
• Fever and chills
• Stomach pain
• Facial hair growth
• Running nose
• Sweating

Quick Suggestions:

• Ciclosporin is used to prevent organ rejection in transplant patients.
• It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels.
• It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
• Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness. 
• Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
• Do not stop taking Ciclosporin without talking to your doctor first.

Indication of Neoral 100mg Capsule

Sandimmun Neoral 100mg Capsule 5's: A Multifaceted Solution

Sandimmun Neoral 100mg Capsule 5's, an 'immunosuppressant,' wears many hats in the medical realm. Here's the scoop:

Organ Rejection Prevention:

• After transplants, it's the guard against organ rejection, by calming the immune system's response.

Pain and Inflammation Tamer:

• In rheumatoid arthritis, it steps in as an inflammation and pain reducer, specifically targeting joint issues.

Skin Savior:

• Severe skin conditions like eczema, psoriasis, and atopic dermatitis find relief under its wing.

Kidney Care:

• Nephrotic syndrome, a kidney ailment, meets a potential ally in Sandimmun Neoral.

Eye Support:

• Eye problems like endogenous uveitis and Behçet's uveitis also come under its therapeutic reach.

Pharmacology

Cyclosporine's Intricate Actions:

Immunosuppressive Pathway:

• First, it binds to cyclophilin.
• This duo then takes down calcineurin, the molecule that normally activates interleukin 2 transcription.
• By doing so, Cyclosporine curbs lymphokine production and the release of interleukins, key immune players.

Ophthalmic Mystery:

• When applied to the eyes, Cyclosporine's action isn't fully revealed.
• In keratoconjunctivitis sicca (dry eye), it's believed to be a partial immunomodulator.
• This means it fine-tunes the immune response in cases where tear production is hampered due to ocular inflammation.

Cyclosporine's diverse roles in immune regulation and ophthalmic care highlight its versatility in addressing complex medical scenarios.

Dosage & Administration of Neoral 100mg Capsule:

Dosing Guidelines for Neoral 100mg Capsule:

Solid Organ Transplantation:

• Initial: 10 to 15 mg/kg in 2 divided doses, starting 12 hours before surgery, continued for 1 to 2 weeks.
• Maintenance: Gradually reach 2 to 6 mg/kg in 2 divided doses.

Bone Marrow Transplantation:

• Initial: 12.5 to 15 mg/kg in 2 divided doses, beginning the day before transplantation.
• Maintenance: Continue 12.5 mg/kg in 2 divided doses for at least 3 to 6 months, gradually decreasing to zero within a year.

Endogenous Uveitis:

• Initial: 5 mg/kg per day in 2 divided doses.
• Maintenance: Slowly reduce to the lowest effective level.

Nephrotic Syndrome:

• Initial: 5 mg/kg (adults), 6 mg/kg (children) in 2 divided doses. Adjust for renal impairment.
• Maintenance: Gradually reduce to the lowest effective level.

Rheumatoid Arthritis:

• Initial: 3 mg/kg per day in 2 divided doses for 6 weeks. Up to 12 weeks may be needed for full effectiveness.
• Maintenance: Adjust individually for tolerability.

Psoriasis & Atopic Dermatitis:

• Initial: 2.5 mg/kg per day in 2 divided doses (5 mg/kg for rapid improvement).
• Maintenance: Titrate to the lowest effective level.

Usage Tips:

• Swallow Neoral 100mg Capsule with water; don't crush or chew.
• Dosage and duration are determined by your doctor based on age, weight, and condition.
• Do not stop without consulting your doctor.

These dosing instructions provide a clear roadmap for taking Neoral 100mg Capsule for various medical conditions. Always follow your doctor's advice for safe and effective treatment.

Interaction

Before using Neoral 100mg Capsule, be sure to inform your doctor if you're taking any of the following medications:

• St. John’s Wort (used for depression)
• Dabigatran etexilate (prevents blood clots after surgery)
• Bosentan or aliskiren (treats high blood pressure)
• Vaccines
• Medicines that raise blood potassium levels (potassium supplements, potassium-sparing diuretics)
• Methotrexate (for cancer, and severe rheumatoid arthritis)
• Antibiotics (erythromycin, azithromycin, etc.)
• Antifungals (voriconazole, itraconazole, etc.)
• Heart-related medications (diltiazem, nicardipine, etc.)
• Metoclopramide (stops nausea, and vomiting)
• Danazol (treats uterine overgrowth)
• Birth control pills (oral contraceptives)
• Medications for gout, gallstones, cancers, and more
• Barbiturates (reduce anxiety, induce sleep)
• Epilepsy drugs (carbamazepine, phenytoin, etc.)
• Medicines for hormonal disorders, weight loss, pain, inflammation, cholesterol
• HIV and hepatitis C medications
• Gastric problem treatments (omeprazole, cimetidine, etc.)
• Antibiotics (trimethoprim, cotrimoxazole)
• Corticosteroids (prednisolone, methylprednisolone)
• Diabetes drugs (repaglinide)

Also, remember:

Drug-Food Interaction:

• Avoid grapes or grapefruit juice while taking Neoral 100mg Capsule to prevent increased side effect risks.

This list ensures your doctor has a clear picture of your medications, helping ensure your safety while using Neoral 100mg Capsule.

Contraindications

Hypersensitivity to Cyclosporine or to any of the excipients of Cyclosporine.

Pregnancy & Lactation

Pregnancy Consideration:

• No sufficient studies on pregnant women.
• Use Cyclosporine during pregnancy only if the benefits outweigh the fetal risks.

Lactation Warning:

• Cyclosporine passes into breast milk.
• Avoid breastfeeding while on Cyclosporine treatment.

Prioritize your health and the well-being of your baby by heeding these pregnancy and lactation guidelines regarding Cyclosporine.

Precautions & Warnings

Cyclosporine Risks and Precautions:

Cancer Risk:

• Lymphomas and skin malignancies are heightened risks with Cyclosporine.
• Caution Patients are to limit UV light exposure to minimize this risk.

Infection Susceptibility:

• Bacterial, fungal, parasitic, and viral infections are potential outcomes.
• Long-term immunosuppressive therapy requires proactive therapeutic strategies.

Renal Changes:

• Early Cyclosporine therapy might temporarily raise serum creatinine and urea levels.
• Dose reduction often addresses this issue.
• Elderly patients need vigilant renal function monitoring.

Maintain a vigilant watch for these potential effects of Cyclosporine, safeguarding your health with appropriate precautions.

Storage Conditions

• Keep Neoral 100mg Capsule out of reach of children
• Store Neoral 100mg Capsule at room temperature